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Zyrtec (cetirizine) is definitely an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose. The most interesting Zyrtec Info. Zyrtec is used to deal with cold or allergic reactions such as sneezing, itching, watery eyes, or runny nose. Zyrtec is also used to deal with itching and swelling due to chronic urticaria (hives).